Uncovering the Hidden Players: Double-negative T Cells in Pediatric HIV and Their Impact on Disease Progression

In pediatric HIV infection, CD4/CD8 ratio normalization and DNT decline depict a more nuanced immune reconstitution than CD4 + recovery alone. Age-dependent DNT trajectories support incorporating DNT monitoring as a complementary biomarker in pediatric ART management.

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Publication Details

Journal
The Pediatric Infectious Disease Journal
Published
2026-02-26
DOI
https://doi.org/10.1097/inf.0000000000005199
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Uncovering the Hidden Players: Double-negative T Cells in Pediatric HIV and Their Impact on Disease Progression

Behiye Benaygül Kaçmaz, Sevim Meşe, Pinar Soguksu, Selda Hançerli Törün et al.
The Pediatric Infectious Disease Journal
HIV Research and Treatment
article

Uncovering the Hidden Players: Double-negative T Cells in Pediatric HIV and Their Impact on Disease Progression

Behiye Benaygül Kaçmaz, Sevim Meşe, Pinar Soguksu, Selda Hançerli Törün, Mavera Uşaklioğlu Erol
article en

Abstract

In pediatric HIV infection, CD4/CD8 ratio normalization and DNT decline depict a more nuanced immune reconstitution than CD4 + recovery alone. Age-dependent DNT trajectories support incorporating DNT monitoring as a complementary biomarker in pediatric ART management.

The Pediatric Infectious Disease Journal
Istanbul University (TR)
Good health and well-being
Openalex Percentile: Top 45%
HIV Research and Treatment
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