Shared immune dysregulation in systemic lupus erythematosus and colorectal cancer: a multi-omics guided discovery of DNASE1L3-centric efferocytosis deficiency
SLE and CRC exhibit overlapping DEGs, immune profiles, and signaling pathways. The model based on the shared genes-<i>DNASE1L3</i>, <i>PTPN14</i>, <i>SELENBP1</i>, and <i>ECRG4</i>-offers novel insights for precise intervention in both diseases.
Authors
- Chengzi Tian
- Duo Chen (ORCID: https://orcid.org/0000-0001-8490-1241)
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-4527-1168)
- Mingcheng Huang (ORCID: https://orcid.org/0000-0002-2807-1973)
- Hui Guan
- Lihuan Zhang
- Ming Zhong
Institutions
- Sun Yat-sen University (CN)
- Southern University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1775776
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00