Evaluating Inhibitor Effects on Pellicle Formation in <i>Bacillus subtilis</i>

Source: Bucher, T., et al. Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors. J. Vis. Exp. (2016)This video demonstrates a pellicle formation assay using Bacillus subtilis to evaluate small-molecule inhibitors that disrupt matrix synthesis and biofilm development, providing a model to screen compounds that selectively inhibit surface-associated growth without affecting free-floating cells.

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Publication Details

Journal
Journal of Visualized Experiments
Published
2026-02-26
DOI
https://doi.org/10.3791/24488
Primary Topic
Bacterial Genetics and Biotechnology
Type
article
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article

Evaluating Inhibitor Effects on Pellicle Formation in Bacillus subtilis

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Journal of Visualized Experiments
Bacterial Genetics and Biotechnology
article

Evaluating Inhibitor Effects on Pellicle Formation in Bacillus subtilis

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Abstract

Source: Bucher, T., et al. Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors. J. Vis. Exp. (2016)This video demonstrates a pellicle formation assay using Bacillus subtilis to evaluate small-molecule inhibitors that disrupt matrix synthesis and biofilm development, providing a model to screen compounds that selectively inhibit surface-associated growth without affecting free-floating cells.

Journal of Visualized Experiments
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Openalex Percentile: Top 40%
Bacterial Genetics and Biotechnology
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