Progressive Transformation of Germinal Centers: A Systematic Review

Progressive transformation of germinal centers (PTGC) is a benign histopathological process, typically manifesting as persistent, painless lymphadenopathy. It is of clinical significance because of its ability to mimic or coexist with other lymphoproliferative disorders. This systematic review summarizes the currently available literature to outline the clinical, pathological, and diagnostic features of PTGC and to identify areas that require further investigations to guide future clinical practice.