Characterizing Longitudinal Molecular Changes in ctDNA in Patients with Metastatic Castration-resistant Prostate Cancer
Our study revealed dynamic shifts in genetic mutations in patients with mCRPC following ARPI, PARPi and taxanes. Furthermore, our findings highlight associations between AR alterations and clinical outcomes, emphasizing the potential for personalized treatment strategies.
Authors
- Justine Panian (ORCID: https://orcid.org/0000-0002-6651-195X)
- Chinmay Jani (ORCID: https://orcid.org/0000-0001-9899-6333)
- Nicole Zhang (ORCID: https://orcid.org/0009-0001-2706-5838)
- Jianjie Dong
- Elizabeth Pan (ORCID: https://orcid.org/0000-0001-7025-9104)
- Eli Tran
- Jill Tsai
- Mrs Leslie Bucheit
- Yu-Wei Chen
- Rana R. McKay
Institutions
- Scripps Research Institute (US)
- University of California, San Francisco (US)
- University of California San Diego (US)
- Guardant (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- University of San Francisco (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3071
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00