Frailty Status Predicts Adverse Outcomes in Ambulatory Heart Failure With Preserved Ejection Fraction
Frailty is common in ambulatory HFpEF. In unadjusted models, frailty is associated with higher risk, but this is attenuated after accounting for congestion and anemia/iron markers, supporting a shared pathophysiologic pathway linking frailty and HFpEF rather than an independent prognostic effect.
Authors
- Joban Vaishnav (ORCID: https://orcid.org/0000-0001-5021-5454)
- Brian Buta (ORCID: https://orcid.org/0000-0002-0752-2456)
- Rishi Trivedi (ORCID: https://orcid.org/0000-0003-3046-4722)
- Virginia S. Hahn (ORCID: https://orcid.org/0000-0002-0578-2668)
- Gary Gerstenblith (ORCID: https://orcid.org/0000-0001-6046-6812)
- Vivek Jani (ORCID: https://orcid.org/0000-0002-3811-4973)
- Masih Tajdini
- Radu Tanacli
- Kavita Sharma
- Jing Tian
- Qian-Li Xue
- Abdulla A. Damluji
Institutions
- Inova Health System (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- JACC Advances
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102560
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00