PFKFB3-driven glycolysis in endothelial cells activates RhoA/ROCK1 to promote pulmonary vascular leakage in heatstroke
PFKFB3-driven glycolysis activates RhoA/ROCK1 to disrupt endothelial barriers in heatstroke. Targeting this metabolic-inflammatory axis may mitigate pulmonary vascular leakage, thus providing a therapeutic strategy against heatstroke induced acute lung injury.
Authors
- Chengjia Ding
- Minghan Deng
- Jing Tuo
- Ping Huang
- Yi Chen
Institutions
- Longgang Central Hospital (CN)
- Dongguan People’s Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.bbadis.2026.168198
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00