Core Epithelial‐to‐Mesenchymal Transition Gene Signature Predicts Metastasis and Poor Survival in Synovial Sarcoma
This study demonstrates a correlation between mesenchymal gene expression signatures and increased metastatic risk in SS. EMT status, derived from primary tumor profiling at diagnosis, may serve as a potential prognostic biomarker. These findings support further investigation into EMT as a stratification tool for tailoring treatment intensity and surveillance strategies in SS.
Authors
- Megan H. Jagosky (ORCID: https://orcid.org/0000-0001-9841-5324)
- Johann H. Hsu
- Jin Guangxu
- Wei Zhang
- Nury Steuerwald
- Anderson O' Brien Cox
- Sharvil Desai
- Alicia Hamilton
- Jenny Chen
- HsihTe Yang
- Colin Anderson
- Mathew Smith
Institutions
- Allina Health (US)
- Levine Cancer Institute (US)
- Wake Forest University (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1002/cam4.71643
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00