High-Fat Diet Anticipates Age-Related Sarcopenia Through Increased Oxidative Stress and Inflammation
In the HFD group the antioxidant defences fail their job because of the additional inflammation and oxidative stress due to the diet. HFD is related to decreased animals' activity. Thus, cannot be excluded that the reduced physical activity may contribute, at least in part, to the impaired mitochondrial functions in the skeletal muscle of HFD rats. Altogether, our results clearly highlighted the contribution of HFD in anticipating and worsening the metabolic and inflammatory alterations associated with aging, including sarcopenia.
Authors
- Gina Cavaliere (ORCID: https://orcid.org/0000-0001-5890-1002)
- Lidia Petrella (ORCID: https://orcid.org/0000-0002-5084-5760)
- F. Cimmino
- Maria Pina Mollica (ORCID: https://orcid.org/0000-0003-2726-7779)
- Giuliana Napolitano
- Marianna Crispino
- Giovanna Trinchese
- Annamaria Colao
- Mariarosaria Negri
- Claudia Pivonello
Institutions
- UNESCO (FR)
- University of Perugia (IT)
- Federico II University Hospital (IT)
- Pegaso University (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- British Journal of Biomedical Science
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/bjbs.2026.15743
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Napoli Federico II
- European Commission