Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.

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Publication Details

Journal
Multiple Sclerosis Journal
Published
2026-02-26
DOI
https://doi.org/10.1177/13524585261424657
Primary Topic
Multiple Sclerosis Research Studies
Type
article
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article

Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

Woojun Kim, Janis Siew Noi Tye, Tatsuro Misu, Hui Jieh Tan et al.
Multiple Sclerosis Journal
Multiple Sclerosis Research Studies
article

Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

Woojun Kim, Janis Siew Noi Tye, Tatsuro Misu, Hui Jieh Tan, N. Park, Shuhei Nishiyama, Sasitorn Siritho, Monalisa Vegda, Tianrong Yeo, Naohiro Sakamoto, Jyh Yung Hor, Lekha Pandit, Ichiro NAKASHIMA, Dong-Eun Lee, Dai Ichikawa, You-Ri Kang, Ho Jin Kim, Su-Hyun Kim, Kuo-Hsuan Chang, Jae-Won Hyun, De-Cai Tian, Kazuo Fujihara, Shanthi Viswanathan, Yun Xu
article en

Abstract

This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.

Multiple Sclerosis Journal
Fukushima Medical University (JP), Siriraj Hospital (TH), Nitte University (IN), Capital Medical University (CN), Tohoku University (JP), Hospital Kuala Lumpur (MY), Chang Gung Memorial Hospital (TW), Beijing Tian Tan Hospital (CN), Chonnam National University Hospital (KR), National Cancer Center (KR), National Neuroscience Institute (SG), Institut Penyelidikan Veterinar (MY), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Tohoku Medical and Pharmaceutical University (JP)
Good health and well-being
Openalex Percentile: Top 43%
Multiple Sclerosis Research Studies
DOISourceOpenAlex
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