Impact of Donor Age and Prolonged Warm Ischemia in Normothermic Machine Perfusion of Rat Livers
This study highlights how donor age and warm ischemia impact the quality of ECD liver grafts. Histological and molecular assessment during NMP may lead to tailored interventions to improve the quality of such grafts, which is not well reflected by conventional parameters. Our findings support the role of NMP in expanding the utilization of ECD grafts amid organ shortages and an aging donor population.
Authors
- Sauer Igor
- Simon Moosburner (ORCID: https://orcid.org/0000-0003-1879-4788)
- Alexander Arnold (ORCID: https://orcid.org/0000-0002-7727-0688)
- Lene Änne Böhne (ORCID: https://orcid.org/0000-0001-9604-1541)
- Oliver Klein (ORCID: https://orcid.org/0000-0001-7984-7607)
- Luca Padoan
- Nathanael Raschzok (ORCID: https://orcid.org/0000-0001-5074-7063)
- Leonard Boerger (ORCID: https://orcid.org/0009-0001-1238-8984)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Karl H. Hillebrandt (ORCID: https://orcid.org/0000-0002-5114-6590)
- Anne Mirja Pietsch
- J. G. M. V. Gassner
- Kilian Alexander Walter
- J. Iske
- Johann Pratschke
Institutions
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Tissue Engineering Part A
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1177/19373341261419492
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00