Trial Design and Objectives for Patients With Prostate Cancer: Recommendations From the Prostate Cancer Working Group 4
PCWG4 updates recommendations on patient and tumor characterization, therapy development, and imaging criteria and extends guidance into earlier androgen pathway modulator-naïve/sensitive disease states to reflect an evolving, heterogeneous, and diverse patient population to optimize treatment benefits for all patients.
Authors
- Dana E. Rathkopf (ORCID: https://orcid.org/0000-0002-4503-7582)
- Joshua M. Lang (ORCID: https://orcid.org/0000-0002-0943-8872)
- Charles J. Ryan (ORCID: https://orcid.org/0000-0002-2081-3557)
- Daniel E. Lage (ORCID: https://orcid.org/0000-0002-6170-2597)
- M. Morris
- Heiko M. Schöder (ORCID: https://orcid.org/0000-0002-5170-4185)
- Daniel S. Childs (ORCID: https://orcid.org/0000-0001-7643-2836)
- Delphine L. Chen (ORCID: https://orcid.org/0000-0002-0150-5401)
- William L. Dahut (ORCID: https://orcid.org/0000-0002-2766-9703)
- P. Nelson
- Alan Haruo Bryce (ORCID: https://orcid.org/0000-0002-0206-3895)
- Ken Hermann
- Nima Sharifi (ORCID: https://orcid.org/0000-0003-1281-3474)
- Julie N. Graff (ORCID: https://orcid.org/0000-0002-5708-2794)
- Elizabeth Riley Kessler (ORCID: https://orcid.org/0000-0001-7285-867X)
- Susan F. Slovin
- Matthew B. Rettig (ORCID: https://orcid.org/0000-0002-7394-3056)
- M. Stein
- Louise Emmett (ORCID: https://orcid.org/0000-0002-4895-7384)
- Kristofer Prepelica
- Nadine Mallak (ORCID: https://orcid.org/0000-0002-3627-6880)
- Kosj Yamoah (ORCID: https://orcid.org/0009-0001-0987-0972)
- Anis Hamid (ORCID: https://orcid.org/0000-0002-7193-9723)
- Nicholas Zorko
- Glenn X. Liu
- Channing Judith Paller (ORCID: https://orcid.org/0000-0003-3658-1858)
- N. Kim.
- Alex Wyatt
- Maha Hussain
- Lauren Schwartz
- MD Thomas A. Hope
- Pedro C. Barata
- Phillip H. Kuo
- Alexandra O. Sokolova
- Ana Aparicio
- Andrei Gafita
- S. Halabi
- Wassim Abida
- Cora N. Sternberg
- Evan Y. Yu
- Michael A. Carducci
- Andrew J. Armstrong
- Charles G. Drake
- Emmanuel S. Antonarakis
- David Nanus
- Alicia K. Morgans
- Catherine H. Marshall
- Joshi J. Alumkal
- Scott T. Tagawa
- Akash Patnaik
- Howard I. Scher
- for the PCWG4 Writing Group
- Michael S. Hofman
- Jones Nauseef
- Daniel J. George
- Karim Fizazi
- Rana R. McKay
- W. Kevin Kelly
- Russell Z. Szmulewitz
- Mary-Ellen Taplin
- Zachery R. Reichert
- Heather H. Cheng
- Himisha Beltran
- Walter M. Stadler
- A. Oliver Sartor
- Elisabeth I. Heath
- Rahul R. Aggarwal
Institutions
- Northwestern University (US)
- American Cancer Society (US)
- BC Cancer Agency (CA)
- City Of Hope National Medical Center (US)
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Wisconsin–Madison (US)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- University of Miami (US)
- Thomas Jefferson University (US)
- Oregon Health & Science University (US)
- The University of Melbourne (AU)
- Duke University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Cornell University (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Peter MacCallum Cancer Centre (AU)
- Institut Gustave Roussy (FR)
- Moffitt Cancer Center (US)
- University of California San Diego (US)
- University of Chicago (US)
- St Vincent's Hospital Sydney (AU)
- Hope Cancer Clinic (US)
- London Cancer (GB)
- James A. Haley Veterans' Hospital (US)
- Fred Hutch Cancer Center (US)
- Presbyterian Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- City of Hope (US)
- Prostate Cancer Research (GB)
- Dana-Farber Cancer Institute (US)
- Essen University Hospital (DE)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- Canada's Michael Smith Genome Sciences Centre (CA)
- Goodyear (United States) (US)
- Duke University Hospital (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Weill Cornell Medicine (US)
- University College London (GB)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1200/jco-25-02834
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 36.44