Outcomes of Burn Patients Admitted Initially to a Non-Burn Center Intensive Care Unit in Romania: A Retrospective Exploratory Study

<i>Background and Objectives</i>: Many burn patients are initially admitted to non-burn center intensive care units (ICUs) due to resource constraints, geographic barriers, or delayed transfer. Their management requires multidisciplinary, phase-specific clinical and assistive practices, yet outcomes from non-specialized centers remain scarce. This study aimed to (1) determine six-month survival among all adult burn patients initially admitted to a non-burn center ICU, (2) identify clinical predictors of mortality, and (3) explore reasons for transfer to burn centers within a resource-limited healthcare setting. <i>Materials and Methods</i>: We conducted a retrospective observational cohort study including 42 adult burn patients initially admitted to the ICU of a regional non-burn hospital in Romania (2019-2024). Of these, 24 were treated entirely in the non-burn center (initially treated in the ICU and then further managed on the same hospital's wards), and 18 were, after initial ICU stabilization, subsequently transferred to burn centers. Six-month survival was assessed using Kaplan-Meier analysis. Logistic regression and Cox proportional hazards models were used to assess associations with mortality. Clinical trajectories and transfer decisions were also analyzed. <i>Results</i>: Six-month survival was 61.9% (95% CI 48.8-78.5), with most deaths occurring within 60 days. Total body surface area (TBSA) (HR 1.05, 95% CI 1.02-1.08, <i>p</i> < 0.001) and acute kidney injury (AKI) (HR 3.48, 95% CI 1.18-10.29, <i>p</i> = 0.024) were independently associated with mortality. Patients transferred to burn centers had greater TBSA (median 35% vs. 15%, <i>p</i> = 0.003), consistent with severity-driven referral decisions. <i>Conclusions</i>: Among all burn patients initially admitted to a non-burn center ICU, six-month survival was 62%, with TBSA and AKI independently associated with mortality in adjusted analyses. These findings underscore the importance of phase-specific, multidisciplinary care pathways, including early resuscitation, renal and hemodynamic monitoring, coordinated nursing care, rehabilitation planning, and transfer protocols to improve outcomes.