Adjuvant Imatinib or Observation in Patients With Gastrointestinal Stromal Tumors With <i>KIT</i> Exon 9 Mutations
In this large international cohort study of resected GISTs with KIT exon 9 mutations, adjuvant imatinib was independently associated with delayed recurrence and improved survival. These findings support the use of adjuvant imatinib in mNIH high-risk GISTs with KIT exon 9 mutations and underscore the need for prospective studies to define optimal dosing and treatment duration.
Authors
- Andrea Napolitano (ORCID: https://orcid.org/0000-0002-7509-1555)
- Alessandro Mazzocca
- Skye C. Mayo (ORCID: https://orcid.org/0000-0002-1631-9855)
- Jozef Šufliarský
- Hans Gelderblom
- Thomas L. Sutton (ORCID: https://orcid.org/0000-0002-2894-7154)
- Valentina Fausti (ORCID: https://orcid.org/0000-0003-0432-1445)
- Maria Abbondanza Pantaleo (ORCID: https://orcid.org/0000-0002-0177-6957)
- Andrea Bordoni (ORCID: https://orcid.org/0000-0003-1235-6170)
- Ingrid M.E. Desar (ORCID: https://orcid.org/0000-0003-0945-8299)
- Chiara Braconi (ORCID: https://orcid.org/0000-0003-4835-1259)
- Peter Reichardt (ORCID: https://orcid.org/0009-0008-1410-3111)
- GLORIA MARQUINA
- Sonja E. Steigen (ORCID: https://orcid.org/0000-0001-8376-2489)
- S Bauer
- Jason J. Luke (ORCID: https://orcid.org/0000-0002-1182-4908)
- Giacomo Giulio Baldi (ORCID: https://orcid.org/0000-0003-0798-7752)
- Johanna Falkenhorst (ORCID: https://orcid.org/0000-0002-4738-7121)
- Trent Jt
- Neeltje Steeghs
- Arun Singh
- Magnús K. Magnússon (ORCID: https://orcid.org/0000-0001-8593-4934)
- Elise F. Nassif (ORCID: https://orcid.org/0000-0003-3794-6759)
- Neeta Somaiah (ORCID: https://orcid.org/0000-0002-0146-7732)
- Claudia Cirilli
- Piotr Rutkowski (ORCID: https://orcid.org/0000-0002-8920-5429)
- Toshiro Nishida
- Kjetil Boye
- Antonella Brunello
- Mariella Spalato Ceruso
- Ferdinando C. M. Cananzi
- Peter Hohenberger
- Alessandro Gronchi
- Denisse Evans
- Bruno Vincenzi
- Winan J. van Houdt
- Nadia Hindi
- Antoine Italiano
- Axel Le Cesne
- Heikki Joensuu
- Bengt Nilsson
- Massimo Federico
- Paolo G. Casali
- Jon G. Jonasson
- Elena Fumagalli
- Javier Martin-Broto
- Sara Rothschild
Institutions
- University of Modena and Reggio Emilia (IT)
- Reykjavík University (IS)
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- University of Helsinki (FI)
- Humanitas University (IT)
- The University of Texas MD Anderson Cancer Center (US)
- Radboud University Nijmegen (NL)
- University of California, Los Angeles (US)
- University of Iceland (IS)
- Oregon Health & Science University (US)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- Hospital Clínico San Carlos (ES)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- University of Miami Health System (US)
- Centre Léon Bérard (FR)
- National University Hospital of Iceland (IS)
- Istituto Oncologico Veneto (IT)
- Essen University Hospital (DE)
- Royal Marsden Hospital (GB)
- Instituto de Biomedicina de Sevilla (ES)
- Institut Bergonié (FR)
- Campus Bio Medico University Hospital (IT)
- VA Portland Health Care System (US)
- National Cancer Center Hospital East (JP)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Candiolo Cancer Institute (IT)
- Istituto Cantonale di Patologia (CH)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Helios Hospital Berlin-Buch (DE)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Sylvester Comprehensive Cancer Center (US)
- IRCCS Humanitas Research Hospital (IT)
- Life Raft Group (US)
- Hospital of Prato (IT)
- Comenius University Bratislava (SK)
- University of Glasgow (GB)
- University of Bologna (IT)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1001/jamaoncol.2026.0007
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00