Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder
Our results may reflect the associations between the disrupted rich club organization and childhood maltreatment in MDD. Furthermore, with exposure to childhood maltreatment, the distinct connection patterns in depressed and healthy populations may indicate neuroimaging features associated with individual vulnerability or resilience to developing MDD in context of early life stress.
Authors
- Jingyi Huang (ORCID: https://orcid.org/0000-0002-1209-9699)
- Lihong Bu (ORCID: https://orcid.org/0000-0002-1102-3158)
- Yang Gao (ORCID: https://orcid.org/0000-0002-1069-2157)
- Haomian Zhao
- Guoqing Gao
- Bei Rong
- Ling Xiao
- Gaohua Wang
- Mingzhe Zhou
- Ning Tu
Institutions
- Anhui Medical University (CN)
- Wuhan University (CN)
- The Fourth People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Anhui Mental Health Center (CN)
- Fourth Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fpsyt.2026.1759133
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan University