Negative influence of age and low baseline CD4 on T helper cell recovery among HIV-infected individuals with fixed-dose combination of tenofovir disoproxil, lamivudine and dolutegravir
The study highlights that, despite viral suppression with TLD, a substantial proportion of patients fail to achieve adequate immune restoration. Lower baseline CD4 was observed to be a key predictor of DIR. These findings underscore the need for early ART initiation, targeted adherence support, and counselling to optimize outcomes and progress toward the UNAIDS 95 target.
Authors
- Yean Kong Yong
- Vijayakumar Velu (ORCID: https://orcid.org/0000-0003-4238-1924)
- Marie Larsson (ORCID: https://orcid.org/0000-0002-4524-0177)
- Sivadoss Raju (ORCID: https://orcid.org/0000-0002-0524-2979)
- B Nisha
- Sathasivam Sivamalar
- Princy Mounika
- Ramachandran Vignesh
- Kannan Rajendran
- Esaki M. Shankar
- Venkatesan Varsha
- Arcot R. Venkateswaran
- Thiyagarajan Vivekanandan
- Madhavan Vidya
- Pachamuthu Balakrishnan
- Sakthi Rengarajan
Institutions
- Linköping University (SE)
- Emory and Henry College (US)
- Meenakshi Academy of Higher Education and Research (IN)
- Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR)
- Xiamen University Malaysia (MY)
- New England Biolabs (China) (CN)
- Public Health Laboratory
- University of Kuala Lumpur (MY)
- Saveetha University (IN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fpubh.2026.1729238
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- Xiamen University
- National Institutes of Health
- Office of Research Infrastructure Programs, National Institutes of Health