ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors

For most scenarios, concurrently combining RT with targeted agents may lead to increased toxicity. Therefore, we recommend a drug interruption, a drug dosage reduction, or a major RT adaptation in various scenarios.

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Publication Details

Journal
ESMO Open
Published
2026-02-26
DOI
https://doi.org/10.1016/j.esmoop.2026.106076
Primary Topic
Melanoma and MAPK Pathways
Type
article
Field-Weighted Citation Impact
0.00

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article

ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors

CB Westphalen, PM Putora, P. Boot, G. Argilés et al.
ESMO Open
Melanoma and MAPK Pathways
article

ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors

CB Westphalen, PM Putora, P. Boot, G. Argilés, F. McDonald, J. Kaźmierska, A. Calles, C.T. Hiley, E. Le Rhun, D. Martins-Branco, C. Belka, K. Konopa, G. Mountzios, E.S.M. van Aken, A. Wrona, A. Prelaj, A.K. Gandhi, B. Muoio, J. Bussink, J. Barriuso, G. Pentheroudakis, V. Atkinson, F. Lordick, J.G. Eriksen, S.M. O’Cathail, U. Ricardi, C.A.M. Marijnen, B. Devnani, D. De Ruysscher, L. Castelo-Branco, M.C. de Jong
article en

Abstract

For most scenarios, concurrently combining RT with targeted agents may lead to increased toxicity. Therefore, we recommend a drug interruption, a drug dosage reduction, or a major RT adaptation in various scenarios.

ESMO OpenVol. 11(3)
Memorial Sloan Kettering Cancer Center (US), Radboud University Nijmegen (NL), University of Zurich (CH), University of St.Gallen (CH), All India Institute of Medical Sciences Jodhpur (IN), European Society for Medical Oncology (CH), Greenslopes Private Hospital (AU), University Hospital of Bern (CH), Cancer Research UK (GB), Princess Alexandra Hospital (AU), Aarhus University Hospital (DK), Radboud University Medical Center (NL), Hospital General Universitario Gregorio Marañón (ES), LMU Klinikum (DE), Research Institute Hospital 12 de Octubre (ES), London Cancer (GB), Ente Ospedaliero Cantonale (CH), University Hospital of Zurich (CH), Hospital Universitario 12 De Octubre (ES), Greater Poland Cancer Center (PL), Royal Marsden Hospital (GB), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL), Dr. Ram Manohar Lohia Institute of Medical Sciences (IN), CRUK Lung Cancer Centre of Excellence (GB), Erasmus MC Cancer Institute (NL), Henry Dunant Hospital (GR), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), University College London (GB), University of Turin (IT), Gdańsk Medical University (PL), Ludwig-Maximilians-Universität München (DE), Leipzig University (DE)
European Society for Medical Oncology
Openalex Percentile: Top 41%
Melanoma and MAPK Pathways
DOIOpen Access PDFOpenAlex
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