Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study
In this largest assessment of biatrial structure and function to date, both left and right atrial cardiopathies were independently associated with increased risk of adverse cardiovascular events. We identified several novel genetic loci for atrial traits and observed unique genetic correlations between left and right atrial traits and cardiovascular phenotypes, providing insight into chamber-specific remodeling. Several of these measures are likely to be causal determinants of cardiovascular complications previously attributed to AF.
Authors
- Eugene Yang (ORCID: https://orcid.org/0000-0003-3945-7529)
- Vidhushei Yogeswaran (ORCID: https://orcid.org/0000-0001-6984-3602)
- Amil M. Shah (ORCID: https://orcid.org/0000-0003-1056-4451)
- Robert W. Rho
- James S. Floyd
- Ting Ye
- Nazem Akoum
- Colleen M. Sitlani
- Jennifer A. Brody
- Kerri L. Wiggins
- Joshua Bis
Institutions
- University of Washington (US)
- Jacobson Holman (United States) (US)
- Cancer Research And Biostatistics (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1161/circep.125.014412
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00