Symptom burden in young adult brain tumor survivors: key intervention targets based on patient-reported outcome network analyses

Lay Summary Young adult survivors of cancer may experience long-term physical, emotional, and social difficulties, particularly after a brain tumor. In this study, we examined how these sequelae relate to one another, rather than considering each outcome separately. Survivors of brain tumors reported a higher overall burden and showed weaker connections between different domains of daily functioning. However, fatigue, physical functioning, work, and sexual difficulties appeared to link multiple aspects of wellbeing. These findings suggest that certain problems may play a central role in shaping long-term quality of life and could be important targets for personalized follow-up care and rehabilitation.

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Publication Details

Journal
Neuro-Oncology Practice
Published
2026-02-23
DOI
https://doi.org/10.1093/nop/npag015
Primary Topic
Childhood Cancer Survivors' Quality of Life
Type
article
Field-Weighted Citation Impact
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article

Symptom burden in young adult brain tumor survivors: key intervention targets based on patient-reported outcome network analyses

Winette T. A van der Graaf, Rhodé M. Bijlsma, Floortje Mols, Janine Nuver et al.
Neuro-Oncology Practice
Childhood Cancer Survivors' Quality of Life
article

Symptom burden in young adult brain tumor survivors: key intervention targets based on patient-reported outcome network analyses

Winette T. A van der Graaf, Rhodé M. Bijlsma, Floortje Mols, Janine Nuver, Jacqueline M. Tromp, Laurien De Roeck, O. Husson, Tom van der Hulle, S Kaal, Ann Hoeben, Charlotte Sleurs, Monique E M M Bos
article en

Abstract

Lay Summary Young adult survivors of cancer may experience long-term physical, emotional, and social difficulties, particularly after a brain tumor. In this study, we examined how these sequelae relate to one another, rather than considering each outcome separately. Survivors of brain tumors reported a higher overall burden and showed weaker connections between different domains of daily functioning. However, fatigue, physical functioning, work, and sexual difficulties appeared to link multiple aspects of wellbeing. These findings suggest that certain problems may play a central role in shaping long-term quality of life and could be important targets for personalized follow-up care and rehabilitation.

Neuro-Oncology Practice
University Medical Center Groningen (NL), Radboud University Nijmegen (NL), Tilburg University (NL), Leiden University Medical Center (NL), Maastricht University Medical Centre (NL), Radboud University Medical Center (NL), University Medical Center Utrecht (NL), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL), Netherlands Comprehensive Cancer Organisation (NL), Erasmus MC Cancer Institute (NL), Amsterdam University Medical Centers (NL), KU Leuven (BE)
Gender equality
Openalex Percentile: Top 42%
Childhood Cancer Survivors' Quality of Life
DOIOpen Access PDFOpenAlex
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