BiToxNet: a deep learning framework integrating multimodal features for accurate identification of neurotoxic peptides and proteins

Overall, BiToxNet provides a powerful and generalizable computational framework for the accurate identification of neurotoxic peptides and proteins. By effectively integrating evolutionary and biochemical information through bilinear attention, BiToxNet offers a valuable tool for neurotoxin screening and protein drug safety assessment, and presents a distinctive modeling strategy applicable to a wide range of biological sequence analysis tasks.

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Publication Details

Journal
BMC Biology
Published
2026-02-26
DOI
https://doi.org/10.1186/s12915-026-02508-8
Primary Topic
vaccines and immunoinformatics approaches
Type
article
Field-Weighted Citation Impact
0.00
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article

BiToxNet: a deep learning framework integrating multimodal features for accurate identification of neurotoxic peptides and proteins

Xiukun Lin, Xi He, Lantian Yao, Tzong-Yi Lee et al.
BMC Biology
vaccines and immunoinformatics approaches
article

BiToxNet: a deep learning framework integrating multimodal features for accurate identification of neurotoxic peptides and proteins

Xiukun Lin, Xi He, Lantian Yao, Tzong-Yi Lee, Jiahui Guan, Chang Liu, Leyi Wei, Feng Wang, Peilin Xie
article en

Abstract

Overall, BiToxNet provides a powerful and generalizable computational framework for the accurate identification of neurotoxic peptides and proteins. By effectively integrating evolutionary and biochemical information through bilinear attention, BiToxNet offers a valuable tool for neurotoxin screening and protein drug safety assessment, and presents a distinctive modeling strategy applicable to a wide range of biological sequence analysis tasks.

BMC Biology
National Yang Ming Chiao Tung University (TW), Xiamen University (CN), Chinese University of Hong Kong, Shenzhen (CN), Macao Polytechnic University (MO), Xiamen University of Technology (CN)
Reduced inequalities
Openalex Percentile: Top 41%
vaccines and immunoinformatics approaches
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