Spatio-temporal dynamics of autophagy-associated genes in macrophage-driven atherosclerosis: an integrated omics and experimental study
SNX5, SMG1, and GSK3A are pivotal regulators of macrophage lipid handling and immune modulation in AS, exhibiting dynamic spatiotemporal expression within plaques. These genes represent promising diagnostic biomarkers and potential therapeutic targets for stabilizing atherosclerotic plaques.
Authors
- Yunyan Li (ORCID: https://orcid.org/0000-0002-1713-342X)
- Hanning Yang
- Lu Yin (ORCID: https://orcid.org/0000-0002-5075-5263)
- Yue Sun (ORCID: https://orcid.org/0000-0003-0564-6380)
- Lirong Xu
- Yuxue Wang
- Wenqi Cao
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fendo.2026.1764263
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China