TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma
TIGIT expression in myeloid cells in the GBM microenvironment is a functional marker of immunosuppressive activity, with TIGIT knockdown reducing IL-13 expression and unmasking the pro-inflammatory activity of NLRP3. This study bolsters our understanding of the immunosuppressive complexities of the GBM microenvironment, and supports attenuation of immunosuppressive myeloid cell activity as a strategy to restore immune function in GBM.
Authors
- Celina Crisman
- Benjamin Himes (ORCID: https://orcid.org/0000-0001-5420-068X)
- Adı́lia Hormigo (ORCID: https://orcid.org/0000-0003-3259-5603)
- Mohammad Asad (ORCID: https://orcid.org/0000-0003-3078-200X)
- Julio Inocencio (ORCID: https://orcid.org/0000-0001-6331-9826)
- Ian F. Parney (ORCID: https://orcid.org/0000-0002-9702-8047)
- Stefan Mitrasinovic (ORCID: https://orcid.org/0000-0001-9681-8808)
- Xingxing Zang
- Patrick Lasala
- Minori Aoki
- Emad Eskandar
- Carly E Baker
Institutions
- Albert Einstein College of Medicine (US)
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/neuonc/noag044
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00