Antibiotics administration during weaning ameliorates intestinal mucosal inflammation in adult mice and their offspring
Long-term antibiotic administration initiated at the weaning stage in male mice improves colitis in adulthood and in their offspring that associates with decreasing miR-10b-5p and miR-200b-3p expression, thus providing a theoretical basis for optimizing the use of antibiotics and prevention of IBD.
Authors
- Xu Xia
- C H Liu (ORCID: https://orcid.org/0000-0002-7644-7023)
- F. Wang
- Z. Liu
- Junyang Cao (ORCID: https://orcid.org/0009-0007-3327-6352)
- Xiaoming Hu (ORCID: https://orcid.org/0000-0001-9661-0257)
- Zhanjun Lu
- Jiali Deng
Institutions
- Shanghai University (CN)
- Chongqing Normal University (CN)
- Shanghai University of Engineering Science (CN)
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- ShanghaiTech University (CN)
- Affiliated Hospital of Nantong University (CN)
- Wujiang District People's Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1741596
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00