Ten-year longitudinal effects of physical activity and apolipoprotein E ..4 genotype on precuneus atrophy in Japanese older adults
Higher habitual MVPA may be associated with slower left precuneus decline in APOE ε4-positive women. As this exploratory three‑way effect was FDR‑nonsignificant, targeted replication is needed to clarify the role of everyday activity in genetically vulnerable groups.
Authors
- Chikako Tange
- Fujiko Ando (ORCID: https://orcid.org/0000-0002-5444-6388)
- Hiroshi Shimokata (ORCID: https://orcid.org/0000-0002-0830-2041)
- Atsumu Yuki (ORCID: https://orcid.org/0000-0001-5345-512X)
- Yukiko Nishita (ORCID: https://orcid.org/0000-0002-2551-9605)
- Rei Otsuka
- Takashi Kato
- Akinori Nakamura
- Shu Zhang
Institutions
- Akebono (Japan) (JP)
- National Center for Geriatrics and Gerontology (JP)
- Nagoya University (JP)
- Kōchi University (JP)
- Nagoya University of Arts and Sciences (JP)
- Aichi Shukutoku University (JP)
Publication Details
- Journal
- Archives of Gerontology and Geriatrics
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.archger.2026.106194
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00