Frontotemporal lobar degeneration complexity: atypical presentations and heterogeneous proteinopathies in five cases
Findings indicate that clinical phenotypes are more influenced by the anatomical distribution of pathology than by the specific molecular substrate. Frequent coexisting proteinopathies and asymmetric involvement contribute to phenotypic variability, reinforcing the role of neuropathological examination of both hemispheres for accurate clinicopathological correlations and definitive etiological diagnosis.
Authors
- Chiara Cutaia
- Alessandra Canazza
- Chiara Calatozzolo (ORCID: https://orcid.org/0000-0003-0165-3495)
- Valentina Medici (ORCID: https://orcid.org/0000-0001-5438-284X)
- Tino Emanuele Poloni (ORCID: https://orcid.org/0000-0002-8463-6879)
- Riccardo Rocco Ferrari (ORCID: https://orcid.org/0000-0002-7314-5046)
- Giulia Negro
- Annalisa Davin
- Camilla Poloni
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Universidade Estadual de Goiás (BR)
- Fondazione Golgi Cenci (IT)
- Dementia UK (GB)
- Piedmont University (US)
- Institute of Neurobiology (BG)
- Azienda Ospedaliera Ospedale Civile di Legnano (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fnins.2026.1774283
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00