Inhaled bovine lactoferrin modulates the p47phox–MPO–NETosis axis in acute lung injury: implications for bioengineered nanomedicine in respiratory infections

These findings identify LTF as a critical dynamic regulator of the p47phox-MPO-NETosis axis in LPS-induced ALI. They also highlight bLF as a promising candidate for further translational evaluation and support the rationale for developing bioengineered, lactoferrin-based nanomedicines aimed at modulating innate immunity and mitigating neutrophil-driven lung injury in respiratory infectious diseases.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-26
DOI
https://doi.org/10.3389/fimmu.2026.1760949
Primary Topic
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Inhaled bovine lactoferrin modulates the p47phox–MPO–NETosis axis in acute lung injury: implications for bioengineered nanomedicine in respiratory infections

Zhongkuo Yu, Hu Xiaoxiang, L Y Xie, Di Lian et al.
Frontiers in Immunology
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
article

Inhaled bovine lactoferrin modulates the p47phox–MPO–NETosis axis in acute lung injury: implications for bioengineered nanomedicine in respiratory infections

Zhongkuo Yu, Hu Xiaoxiang, L Y Xie, Di Lian, Yaru Liu, Guoan Xiang, ShouLong Deng, Xin Li, JingChao Cao
article en

Abstract

These findings identify LTF as a critical dynamic regulator of the p47phox-MPO-NETosis axis in LPS-induced ALI. They also highlight bLF as a promising candidate for further translational evaluation and support the rationale for developing bioengineered, lactoferrin-based nanomedicines aimed at modulating innate immunity and mitigating neutrophil-driven lung injury in respiratory infectious diseases.

Frontiers in ImmunologyVol. 17
Chinese PLA General Hospital (CN), Ministry of Agriculture (LV), Ministry of Agriculture (ID), Model Animal Research Center (CN), Beijing University of Agriculture (CN), China Agricultural University (CN)
National Natural Science Foundation of China, National Science and Technology Major Project
Good health and well-being
Openalex Percentile: Top 41%
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
DOIOpen Access PDFOpenAlex
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