Hepatic zinc deficiency dampens the acute phase response in patients with alcohol-associated hepatitis
Together, these data suggest that hepatic zinc stores among patients with alcohol-associated hepatitis are reduced, resulting in deficient acute-phase responses. Increasing hepatic zinc stores via supplementation and dietary modulation may improve acute responses to infection, and thus, long term outcomes in this patient group.
Authors
- J. Richard George
- Romario Nguyen (ORCID: https://orcid.org/0000-0002-0237-9523)
- Benjamin L. Woodham (ORCID: https://orcid.org/0000-0001-9527-188X)
- Brian Gloss (ORCID: https://orcid.org/0000-0001-7695-4394)
- Lawrence Yuen (ORCID: https://orcid.org/0000-0003-0287-795X)
- Golo Ahlenstiel (ORCID: https://orcid.org/0000-0003-0026-1457)
- L. Qiao
- Matthew D. Shoulders (ORCID: https://orcid.org/0000-0002-6511-3431)
- Jimin Yoon (ORCID: https://orcid.org/0000-0002-7010-082X)
- Scott Read (ORCID: https://orcid.org/0000-0001-6775-2061)
- Vincent Kwok Lim Lam
- Thomas Tu
- Mehdi Ramezani-Moghadam
Institutions
- Broad Institute (US)
- Blacktown & Mount Druitt Hospital (AU)
- Westmead Hospital (AU)
- Westmead Institute (AU)
- Sydney Local Health District (AU)
- Westmead Institute for Medical Research (AU)
- Western Sydney University (AU)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1642163
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences