Monocyte Titin Gene Expression as a Biomarker of Left Ventricular Dysfunction in Acute Myocarditis

These findings support a pathophysiological link between TTN-related pathways in peripheral immune cells and myocardial injury in acute myocarditis and raise the hypothesis that TTN expression in PBMCs may serve as a novel biomarker of disease severity and long-term ventricular remodeling. Further studies in larger cohorts are warranted to validate these results and to elucidate the mechanistic role of titin in immune-cardiac cross-talk.

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Publication Details

Journal
Genes
Published
2026-02-26
DOI
https://doi.org/10.3390/genes17030268
Primary Topic
Cardiomyopathy and Myosin Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Monocyte Titin Gene Expression as a Biomarker of Left Ventricular Dysfunction in Acute Myocarditis

E. M. Kallergis, Evangelos Zacharis, V. Katsi, Ioannis Kopidakis et al.
Genes
Cardiomyopathy and Myosin Studies
article

Monocyte Titin Gene Expression as a Biomarker of Left Ventricular Dysfunction in Acute Myocarditis

E. M. Kallergis, Evangelos Zacharis, V. Katsi, Ioannis Kopidakis, Konstantinos Fragkiadakis, Emmanouil Kampanieris, Spyridon Maragkoudakis, George Kochiadakis, Emmanouil Simantirakis, Aleksi Sallo, Nick Kopidakis, Onoufrios Malikidis, Gabriela Lilikaki, Ioanna Kontaraki, Emmanouil Marakas Sideras
article en

Abstract

These findings support a pathophysiological link between TTN-related pathways in peripheral immune cells and myocardial injury in acute myocarditis and raise the hypothesis that TTN expression in PBMCs may serve as a novel biomarker of disease severity and long-term ventricular remodeling. Further studies in larger cohorts are warranted to validate these results and to elucidate the mechanistic role of titin in immune-cardiac cross-talk.

GenesVol. 17(3)
University of Crete (GR), Ippokrateio General Hospital of Thessaloniki (GR), Chania General Hospital ”St. George” (GR), Hippocration General Hospital (GR)
Openalex Percentile: Top 47%
Cardiomyopathy and Myosin Studies
DOIOpen Access PDFOpenAlex
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