The Environmental Health Language Collaborative (EHLC) Adverse Outcome Pathway (AOP) Standards Workshop Report
<ns7:p> The Environmental Health Language Collaborative (EHLC), established in 2021, is a community of practice dedicated to advancing environmental health research by promoting standardized language to achieve harmonized datasets and interoperable tools. EHLC works through several mechanisms, including holding different events to communicate progress and discuss issues, hosting working groups to advance solutions, and conducting webinars and workshops. The recent EHLC AOP Standards two-day workshop served as a platform to connect the Adverse Outcome Pathway (AOP) community with other aligned groups, including the Biomedical Knowledge Graph, New Approach Methodologies (NAMs), Artificial Intelligence and Natural Language Processing (AI/NLP), Human Exposome, and the Data Sharing and Standards communities. With many emerging activities across the biomedical and AOP domains, EHLC is fostering collaboration and knowledge exchange among them. The workshop aimed to raise awareness, enhance alignment across communities, and gather insights to guide future efforts—particularly in improving knowledge and data generation, and advancing the automated and semi-automated integration of biomedical and related human health data with AOPs. <ns7:italic>This manuscript does not necessarily represent US Environmental Protection Agency (US EPA) policy.</ns7:italic> </ns7:p>
Authors
- Jennifer Fostel (ORCID: https://orcid.org/0000-0001-5858-4393)
- Virginia K. Hench (ORCID: https://orcid.org/0000-0002-3612-8036)
- Anne Thessen
- Penny Nymark (ORCID: https://orcid.org/0000-0002-3435-7775)
- Sierra Moxon (ORCID: https://orcid.org/0000-0002-8719-7760)
- Julia M. Malinowska (ORCID: https://orcid.org/0000-0001-6565-2980)
- Maria Shatz (ORCID: https://orcid.org/0000-0002-6981-5174)
- David E. Hines (ORCID: https://orcid.org/0000-0002-7852-3245)
- Nyssa Tucker
- Grace A. Chappell (ORCID: https://orcid.org/0000-0002-7543-8336)
- Marvin Martens (ORCID: https://orcid.org/0000-0003-2230-0840)
- Holly M. Mortensen (ORCID: https://orcid.org/0000-0002-3180-5229)
- Helena T. Högberg (ORCID: https://orcid.org/0000-0001-8034-6818)
- Madison Feshuk (ORCID: https://orcid.org/0000-0002-1390-6405)
- HC Bledsoe
- Scott K. Lynn
- Vikas Kumar
- Samantha Hall
- Julija Filipovska
- Karamarie Fecho
- Harry Caufield
- James Balhoff
- Allen Peter Davis
- Alexander Tropsha
Institutions
- University of North Carolina at Chapel Hill (US)
- Environmental Protection Agency (US)
- University of North Carolina Health Care (US)
- North Carolina State University (US)
- Lawrence Berkeley National Laboratory (US)
- RTI International (US)
- The Open Group (GB)
- European Commission (BE)
- Federal Institute for Risk Assessment (DE)
- Stockholm County Council (SE)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- Office of Science (US)
- National Institute of Environmental Health Sciences (US)
- National Center for Environmental Assessment (EPA) (US)
- Joint Research Centre (IT)
- The Eden Rivers Trust (GB)
- Professional Solutions (United States) (US)
- Office of Disease Prevention (US)
- Environmental Protection Agency (IE)
- Universitat Rovira i Virgili (ES)
- ICF International (United States) (US)
- Renaissance Computing Institute (US)
Publication Details
- Journal
- F1000Research
- Published
- 2026-02-26
- DOI
- https://doi.org/10.12688/f1000research.175826.1
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00