1,2,3-Triazole Nucleoside Analogues with a N-Acetyl-D-glucosamine Residue. Synthesis and Cytotoxic Activity
A series of 1,2,3-triazole nucleoside analogues containing an N-acetyl-D-glucosamine residue was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3,4,6-tri-O-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide with N-propargyl derivatives of phenothiazine, carbazole, isatin, phthalimide, and imidazolin-2-one. The synthesized compounds demonstrated moderate in vitro cytotoxicity against human cancer cell lines M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.
Authors
- Anna P. Lyubina (ORCID: https://orcid.org/0000-0002-2816-8142)
- B. F. Garifullin (ORCID: https://orcid.org/0000-0002-7590-3832)
- Andrey Bogdanov
- O. B. Andreeva
- Almir S. Gazizov (ORCID: https://orcid.org/0000-0001-9899-9606)
- В. Е. Катаев (ORCID: https://orcid.org/0000-0002-2767-2793)
- Ravil F. Aznagulov
- Maya G. Belenok
- Alexandra D. Voloshina
- Leysan R. Safargalieva
Institutions
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
- Kazan State Technological University (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1134/s1070363225606623
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00