Effects of mitochondrial gene mutation 8923 (A→G) on inflammatory indicators and blood pressure after acute high-altitude exposure
The A8923G point mutation acts as a protective locus against AMS. It was associated with lower high-altitude SBP (more pronounced at night), reduced CRP and elevated HDL-C, possibly by inhibiting inflammation and enhancing blood pressure regulation post high-altitude exposure.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0002-8928-8674)
- Ruizhe Li (ORCID: https://orcid.org/0000-0003-4697-8947)
- Minglei Zhang
- Zongbin Li
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Chinese Medical Center (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fphys.2026.1777284
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- General Hospital of People’s Liberation Army