Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation
Leaflet-specific organic fibrotic remodeling actively involves FVR beyond functional adaptation, with distinct fibrotic mechanisms in FMR versus FTR. PDK4 and IFN modulation demonstrate therapeutic potential for FTR.
Authors
- Weiteng Wang
- Jinping Liu (ORCID: https://orcid.org/0000-0002-9384-4880)
- Hongjie Shi (ORCID: https://orcid.org/0009-0008-7917-3241)
- Songren Shu (ORCID: https://orcid.org/0000-0001-8659-197X)
- Xing Chen (ORCID: https://orcid.org/0000-0002-3363-3301)
- Shen Song (ORCID: https://orcid.org/0000-0001-9126-7840)
- Xianqiang Wang (ORCID: https://orcid.org/0000-0003-0602-6765)
- Fuyu Han
- H. H. Hu
- Xiao Chen
- Jiangping Song
- Xiaohu Wang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Wuhan University (CN)
- Hubei University Of Economics (CN)
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1161/atvbaha.125.324134
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00