Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review
<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in <i>H. pylori</i>-associated malignancies. This review summarizes the role of mitochondrial stress in <i>H. pylori</i> infection, gastric cancer, and MALT lymphoma.
Authors
- Éva Margittai (ORCID: https://orcid.org/0000-0003-0841-0613)
- Viola Varga
- Buket Bagci
- Edina A. Wappler-Guzzetta (ORCID: https://orcid.org/0000-0002-2195-5960)
- András Gelley
- Ibolya Czegle
Institutions
- Semmelweis University (HU)
- Boston Medical Center (US)
- University of Rochester Medical Center (US)
- Saint John's Hospital (BE)
- Hospital of the Brothers of St. John of God (AT)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3390/antiox15030285
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00