Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in <i>H. pylori</i>-associated malignancies. This review summarizes the role of mitochondrial stress in <i>H. pylori</i> infection, gastric cancer, and MALT lymphoma.

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Journal
Antioxidants
Published
2026-02-25
DOI
https://doi.org/10.3390/antiox15030285
Primary Topic
Helicobacter pylori-related gastroenterology studies
Type
article
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0.00
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article

Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

Éva Margittai, Viola Varga, Buket Bagci, Edina A. Wappler-Guzzetta et al.
Antioxidants
Helicobacter pylori-related gastroenterology studies
article

Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

Éva Margittai, Viola Varga, Buket Bagci, Edina A. Wappler-Guzzetta, András Gelley, Ibolya Czegle
article en

Abstract

<i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in <i>H. pylori</i>-associated malignancies. This review summarizes the role of mitochondrial stress in <i>H. pylori</i> infection, gastric cancer, and MALT lymphoma.

AntioxidantsVol. 15(3)
Semmelweis University (HU), Boston Medical Center (US), University of Rochester Medical Center (US), Saint John's Hospital (BE), Hospital of the Brothers of St. John of God (AT)
Good health and well-being
Openalex Percentile: Top 42%
Helicobacter pylori-related gastroenterology studies
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