Inflammatory markers associated with albuminuria and early atherosclerosis in type 2 diabetic kidney disease: a cross-sectional study
Albuminuria was positively associated with heightened systemic and cellular inflammation, and several inflammatory markers were also associated with greater CIMT and the presence of early atherosclerosis. Exploratory mediation analyses suggested that inflammatory pathways may partly account for the association between albuminuria and SA, with IL6, IL1β, and TLR2 as key mediators; however, these findings should be interpreted cautiously due to the cross-sectional design.
Authors
- Ainhoa González-Luis
- Andrea Reyes-Carrión (ORCID: https://orcid.org/0000-0003-1028-2083)
- Orlando Siverio-Morales
- Carolina Hernández-Carballo (ORCID: https://orcid.org/0000-0002-5801-7687)
- Ernesto Martín-Núñez
- Javier Donate-Correa
- Juan F. Navarro-González
- Carmen Mora-Fernández
- J. Diego Carlos-Monzón
Institutions
- Universidad de La Laguna (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Universidad Fernando Pessoa Canarias (ES)
- Sociedad Española de Nefrología (ES)
- Navarrabiomed (ES)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fendo.2026.1732900
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Salud Carlos III