Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo kinases. During schizogony, asynchronous nuclear replication produces a multinucleate schizont, while rapid male gametogony generates an octaploid nucleus before gamete formation. Here, we identify Aurora-related kinase 1 (ARK1) as a key component of inner MTOC and spindle formation, controlling kinetochore dynamics and driving mitotic progression. Conditional ARK1 depletion disrupts spindle biogenesis, kinetochore segregation, karyokinesis and cytokinesis in both stages, and affects parasite transmission. Interactome analysis shows that ARK1 forms the catalytic core of a non-canonical chromosomal passenger complex (CPC) containing two highly divergent inner centromere proteins (INCENPs), which we term INCENP-A and INCENP-B, and lacking the canonical chromatin-targeting subunits Survivin and Borealin. Comparative genomics suggests that apicomplexan INCENPs arose through recurrent lineage-specific duplications, reflecting an evolutionary rewiring of CPC architecture in this eukaryotic lineage. Together, these findings reveal key adaptations in Plasmodium mitosis involving ARK1 and its INCENP scaffolds, and identify the ARK1-INCENP interface as a potential multistage target for antimalarial intervention.
Authors
- Declan Brady (ORCID: https://orcid.org/0000-0001-9150-7840)
- Andrew R. Bottrill (ORCID: https://orcid.org/0000-0002-5182-3643)
- Akancha Mishra (ORCID: https://orcid.org/0009-0005-4775-3338)
- Pushkar Sharma (ORCID: https://orcid.org/0000-0001-6861-0508)
- Eelco C. Tromer (ORCID: https://orcid.org/0000-0003-3540-7727)
- Mohammad Zeeshan (ORCID: https://orcid.org/0000-0002-6185-403X)
- Anthonius A. Eze (ORCID: https://orcid.org/0000-0002-4821-1689)
- Ryuji Yanase (ORCID: https://orcid.org/0000-0001-9419-398X)
- Sarah L. Pashley (ORCID: https://orcid.org/0000-0002-9948-1777)
- David S. Guttery (ORCID: https://orcid.org/0000-0003-0418-580X)
- Anthony A. Holder (ORCID: https://orcid.org/0000-0002-8490-6058)
- Sue Vaughan (ORCID: https://orcid.org/0000-0002-0925-4491)
- Jean‐Philippe David (ORCID: https://orcid.org/0000-0002-3950-5909)
- Edward Rea (ORCID: https://orcid.org/0000-0001-9826-3981)
- Steven Abel (ORCID: https://orcid.org/0000-0002-4361-3443)
- K G Le Roch
- Annu Nagar
- Rita Tewari
Institutions
- University of California, Riverside (US)
- Oxford Brookes University (GB)
- University of Nottingham (GB)
- University of Groningen (NL)
- Central Drug Research Institute (IN)
- The Francis Crick Institute (GB)
- University of Warwick (GB)
- National Institute of Immunology (IN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1038/s41467-026-69460-7
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00