Changes in gene regulation are associated with the evolution of resistance to a novel parasite
Our results provide strong evidence that changes in gene regulation and increased negative feedback to mitigate immunopathology are essential steps in the evolutionary co-option of an existing pathway to defend against a new parasite infection.
Authors
- Joseph M. Marini (ORCID: https://orcid.org/0000-0002-9042-3327)
- Amanda K. Hund (ORCID: https://orcid.org/0000-0001-7758-6757)
- Mariah L. Kenney (ORCID: https://orcid.org/0000-0003-4884-108X)
- Lauren E. Fuess (ORCID: https://orcid.org/0000-0003-0197-7326)
- Meghan F. Maciejewski
- Daniel I. Bolnick
Institutions
- Texas State University (US)
- University of Connecticut (US)
- University of Illinois Urbana-Champaign (US)
- Carleton College (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1697157
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00