Ectoine attenuates H2O2-Induced cellular senescence in human keratinocytes and endothelial cells by modulating the p53/p21 and p16 pathways
Ectoine exerts potent anti-senescence effects in H<sub>2</sub>O<sub>2</sub>-induced models of skin-related cell senescence, primarily by modulating the p53/p21 and p16 signalling pathways and reducing oxidative damage. These findings may support further exploration of its potential application in anti-cellular senescence research.
Authors
- Zengqiang Miao
- Meini Li
- Yongzhen Li (ORCID: https://orcid.org/0000-0002-2990-3655)
- Yi Yi
- Jingyue Zhang
- Xiang Gao
- Yanran Pai
- Wenke Yang
- Jie Shuang
Institutions
- Qinghai University (CN)
- Guigang City People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fragi.2026.1754569
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China