Enantioselective Synthesis of Seven-Membered Bridged Biaryls via Pd-Catalyzed Asymmetric Annulative Allylic Alkylation

An enantioselective formal [5+2] annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of <i>o</i>-indolizinyl <i>N</i>-sulfonylanilines with (<i>Z</i>)-butene dicarbonate. This reaction features mild conditions, excellent enantioselectivity, and a broad substrate scope. The potential scalability and late-stage elaboration demonstrate the practicality of this protocol.