The effect of Toxoplasma gondii infection in parental male mice on the transcriptome of their offspring’s brain
T. gondii infection of male parental mice significantly downregulates gene expression in the brain tissue of their offspring and negatively regulates the immune system and signal transduction pathways. This study provides valuable insights into the intergenerational effects of T. gondii infection and highlights the importance of further research in this critical area.
Authors
- Gui-hua Zhao
- Hongjie Dong (ORCID: https://orcid.org/0000-0002-2447-1523)
- Huan Xie (ORCID: https://orcid.org/0000-0001-8627-8342)
- Hongtao Li (ORCID: https://orcid.org/0000-0002-9377-6734)
- Hang Sun (ORCID: https://orcid.org/0000-0002-2302-1993)
- Xiaoman Xie
- Chao Xu
- Ya-Nan Li
- Jian Ma
- Kun Yin
- Yan-Han Hou
- Xin-Yuan Zhou
Institutions
- Shandong First Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1186/s13071-026-07302-7
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00