Dental microplastics as emerging neurotoxicants: a systematic review on human data

Current evidence indicates possible neurological effects of microplastics-related exposures, corroborated by similar molecular pathways in <i>in-vitro</i> research and connections identified in human cross-sectional data. Nevertheless, the primarily observational and experimental characteristics of existing studies hinder definitive conclusions about clinical causation. Additional longitudinal, standardized human investigations are required to elucidate dose-response relationships and the applicability of <i>in-vitro</i> findings to real-world exposure.