Neonatal jaundice and the infant gut microbiome: an integrated shotgun metagenomics and bidirectional Mendelian randomization study in Xinjiang
Neonatal pathologic jaundice is associated with distinctive compositional and functional alterations in the gut microbiome. Genetic evidence from MR supports a potential causal contribution of specific microbial pathways to jaundice risk, highlighting candidate targets for microbiome-based prevention or adjunctive therapy in early life.
Authors
- Jinyong Pan
- Y. W. Zhang
- Muqing Niu (ORCID: https://orcid.org/0009-0009-4549-9574)
- Yonglin Chen
- Fengling Zhang
- Hua Guan
- Yan Guo
- Xiaoping Yang
- Hu Li
- Heyun Xiong
Institutions
- Shihezi University (CN)
- Xinjiang Production and Construction Corps (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fmicb.2026.1761712
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Production and Construction Corps