Interpretability of an FDA-authorized AI/ML sepsis diagnostic tool improved by SHAP values
These results suggest health care providers value transparency into AI/ML algorithms designed for clinical use, and that Shapley values are a useful approach to providing that transparency, which in turn may improve tool adoption and clinical utility.
Authors
- Scott Smith
- Ashok Palagiri
- Nicholas Maddens
- Tatyana Shvilkina
- J. H. Lee
- Akhil Bhargava
- Carmen DeMarco
- Neil R. Evans (ORCID: https://orcid.org/0000-0001-5602-2370)
- Stockton Mayer (ORCID: https://orcid.org/0000-0002-9688-5469)
- Kurian Thomas (ORCID: https://orcid.org/0000-0003-0955-4758)
- Ramona Berghea
- Falgun Gosai
- Andrew Friederich
- B. Stenson
- Aimee Espinosa
- Roneil G. Malkani (ORCID: https://orcid.org/0000-0002-6712-4003)
- Carlos G. Lopez-Espina
- Grace L. Staples
- Alexandra Halalau (ORCID: https://orcid.org/0000-0002-1805-992X)
- Clinton Ezekiel (ORCID: https://orcid.org/0000-0003-4619-4253)
- Amanda Doodlesack
- Peter S. Antkowiak (ORCID: https://orcid.org/0000-0002-6857-8277)
- Alon Dagan (ORCID: https://orcid.org/0000-0002-3404-9983)
- Sihai Dave Zhao (ORCID: https://orcid.org/0000-0001-5980-5071)
- Vikram Oke (ORCID: https://orcid.org/0000-0003-0305-0268)
- Lekshminarayan Raghavakurup (ORCID: https://orcid.org/0009-0009-9789-5974)
- Lavneet Chawla
- Deesha Sarma (ORCID: https://orcid.org/0000-0003-1970-9290)
- Eric Reseland
- Muleta Tafa
- Hugo Dávila
- Francisco R. Davila
- Niko Kurtzman
- Aamer Syed (ORCID: https://orcid.org/0000-0002-7499-3725)
- M.J. Crisp
- Saleem Azad
- Roshni Patel (ORCID: https://orcid.org/0000-0003-1493-8844)
- Matthew Sims
- Samuel Raouf
- Ruoqing Zhu
- Farhan Ali
- Lee Schmalz
- Bobby Reddy
- Gregory Watson
- Rashid Bashir
- Max S Kravitz
- Nathan I Shapiro
- Karthik Iyer
- Farid Sadaka
- Robin Carver
- Sahib Singh
Institutions
- Beth Israel Deaconess Medical Center (US)
- Emory Healthcare (US)
- Harvard University (US)
- Emory University (US)
- University of Illinois Urbana-Champaign (US)
- Chicago Institute for Psychoanalysis (US)
- OSF Saint Francis Medical Center (US)
- Beaumont Hospital, Royal Oak (US)
- Jesse Brown VA Medical Center (US)
- Mercy Hospital (US)
- Jefferson Hospital (US)
- LifeBridge Health (US)
- University of California, Davis (US)
Publication Details
- Journal
- JAMIA Open
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/jamiaopen/ooag020
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 0.00