Hepatocyte-Specific Knockout of YAP Protects Against Atherosclerosis via Inhibition of ANGPTL3 in Mice
Taken together, our findings revealed a novel role for the YAP-TEAD4-ANGPTL3 axis in lipid metabolism independent of LDLR. Inhibition of hepatocyte YAP may be an effective lipid-lowering strategy for homozygous familial hypercholesterolemia.
Authors
- Xia Sun (ORCID: https://orcid.org/0009-0003-1982-3568)
- Qiaohong Qin
- Y Chen
- Min Jia (ORCID: https://orcid.org/0000-0002-4972-8110)
- Ying Hou (ORCID: https://orcid.org/0000-0002-9303-284X)
- Xingli Su
- Xin Zhang
Institutions
- Xi'an Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1161/atvbaha.125.324122
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00