Gentiopicroside alleviates type 2 diabetes mellitus by attenuating oxidative stress and reshaping gut microbiota in high-fat diet and streptozotocin-induced mice
In conclusion, these results indicated that GPS can reshape the structural composition and diversity of GM, activate the hepatic Nrf2/Keap1 pathway, and maintain glucose homeostasis.
Authors
- Linlin Wu
- Hongxia Li (ORCID: https://orcid.org/0000-0002-1440-1345)
- Peng Xie (ORCID: https://orcid.org/0000-0002-4738-393X)
- Maoting Zhou
- Qi Xie (ORCID: https://orcid.org/0000-0003-2177-7348)
- Dongmei Long
- Xing Wang
- Siyao Luo
- Tian Zhou
Institutions
- North Sichuan Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Zhengzhou Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fnut.2026.1768857
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00