Haplotype-resolved T2T gap-free genomes of the winegrape cultivar Cabernet Sauvignon
Cabernet Sauvignon (CS), a cultivar of winegrape (Vitis vinifera), is among the most renowned winegrape varieties globally. In this study, we released the haplotype-resolved telomere-to-telomere (T2T) CS genome assembled using a combination of PacBio HiFi, ONT ultra-long, and Hi-C sequencing data. The two T2T gap-free haplotype-resolved assemblies CS-T2T.Hap1 and CS-T2T.Hap2 sized 491.11 Mb (contig N50 = 25.09 Mb) and 491.90 Mb (contig N50 = 25.51 Mb), respectively. Genome annotation predicted a total of 36,456 genes in CS-T2T.Hap1 and 35,471 genes in CS-T2T.Hap2. By genome comparison, we discovered and validated megabase inversion events on Chromosome 03,11,18 and 19, which are not prevalent in other haplotype-resolved V. vinifera genomes. In summary, this haplotype-resolved T2T genome represents an essential genomic resource for Cabernet Sauvignon, and lays the foundation for its genetic studies, improvement and utilization.
Authors
- Naomi Abe‐Kanoh (ORCID: https://orcid.org/0000-0002-5091-9133)
- Ying Hua Su (ORCID: https://orcid.org/0000-0002-6071-9565)
- Xiangfeng Wang (ORCID: https://orcid.org/0009-0008-2883-8282)
- Xuenan Zhang (ORCID: https://orcid.org/0000-0002-7072-2784)
- Tiepeng Sun
- Li Guo
- Wenxiu Ye
- Falak Sher Khan
Institutions
- Yamagata University (JP)
- Iwate University (JP)
- Weifang University (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Scientific Data
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1038/s41597-026-06910-3
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province
- Key Technology Research and Development Program of Shandong