RGS19 is associated with prognosis and immune infiltration in glioma: an integrated bioinformatics analysis

The regulator of G-protein signaling (RGS) family is involved in the malignant progression of several cancers, but has not been adequately studied in glioma. Six RGS genes with differential expression were evaluated using differential expression analysis. Four genes, including RGS19, which correlated with the prognosis, were screened. A nomogram was completed by the 'rms' package. The correlation between RGS19 and immune infiltration was analyzed using the TIMER website, the 'GSVA' and 'estimate' packages. The GO and KEGG annotation analyses were completed by the 'clusterProfiler' package to screen potential signaling pathways associated with RGS19.

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Publication Details

Journal
Computer Methods in Biomechanics & Biomedical Engineering
Published
2026-02-26
DOI
https://doi.org/10.1080/10255842.2026.2635006
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

RGS19 is associated with prognosis and immune infiltration in glioma: an integrated bioinformatics analysis

Shuigang Lei, Bozhou Lin, Guiyuan Wang, Tao Wang
Computer Methods in Biomechanics & Biomedical Engineering
Ferroptosis and cancer prognosis
article

RGS19 is associated with prognosis and immune infiltration in glioma: an integrated bioinformatics analysis

Shuigang Lei, Bozhou Lin, Guiyuan Wang, Tao Wang
article en

Abstract

The regulator of G-protein signaling (RGS) family is involved in the malignant progression of several cancers, but has not been adequately studied in glioma. Six RGS genes with differential expression were evaluated using differential expression analysis. Four genes, including RGS19, which correlated with the prognosis, were screened. A nomogram was completed by the 'rms' package. The correlation between RGS19 and immune infiltration was analyzed using the TIMER website, the 'GSVA' and 'estimate' packages. The GO and KEGG annotation analyses were completed by the 'clusterProfiler' package to screen potential signaling pathways associated with RGS19.

Computer Methods in Biomechanics & Biomedical Engineering
Jingning County People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 43%
Ferroptosis and cancer prognosis
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