From Widespread Cutaneous to Systemic Nodal Involvement: Serial FDG PET/CT Findings in Follicular Lymphoma

A 57-year-old woman with follicular lymphoma (FL) presented with diffuse cutaneous and subcutaneous involvement on baseline 18F-FDG PET/CT. Following therapy, cutaneous uptake largely resolved; however, follow-up PET/CT demonstrated new, widespread confluent hypermetabolic lymphadenopathy, indicating systemic progression. This striking post-therapy redistribution highlights the importance of serial whole-body PET/CT in atypical FL.