Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 axis to prevent MASH
Collectively, our study establishes a novel regulatory axis, ZNF384/KIF13B/STT3A/CTSD/THBS1, essential for macrophage-hepatocyte crosstalk during MASLD progression and provides potential therapeutic targets for the treatment of MASLD.
Authors
- L Q Zhang
- Y. J. Su (ORCID: https://orcid.org/0009-0000-2035-8489)
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Xian Xia (ORCID: https://orcid.org/0000-0001-5929-9332)
- Lei He (ORCID: https://orcid.org/0000-0002-1019-182X)
- Si Mei (ORCID: https://orcid.org/0000-0002-4263-1121)
- Ziwei Wang (ORCID: https://orcid.org/0000-0002-7584-3067)
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- W. -X. Huang
- Guolin Miao
- Yinqi Zhao
- Lianxin Zhang
- Xianqin Shen
- Aiden Xian
- Kaikai Lu
- Yufei Han
- Ziyang Guo
- Lin Yao
- Chao Zhai
- Zihao Zhou
- Yuhui Wang
Institutions
- Peking University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Plano Cancer Institute (US)
- Peking University First Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1097/hep.0000000000001726
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00