Impact of cross-linking stoichiometry on the structure and allergenicity of glutaraldehyde-polymerized allergen extracts
Cross-linking stoichiometry critically shapes the structural and immunological properties of polymerized allergen extracts. Adjusting the glutaraldehyde-to-protein ratio to produce highly polymerized, dense polymers enables a well-balanced profile of safety and efficacy for use in AIT.
Authors
- Irene Real-Arévalo
- Diego García-Puentes
- Salvador Iborra (ORCID: https://orcid.org/0000-0002-1607-1749)
- José Fernando Cantillo (ORCID: https://orcid.org/0000-0002-6736-1527)
- Marcos Luengo Viñuela
- Miguel Fernández-Arquero
- E. Nuñez-Borque
- Jose Luis Subiza
- Maria Vila-Gonzalo
- Lucia Moreno-Serna
- Rodrigo Jiménez-Saiz
- Sandra Sivill
Institutions
- Universidad de Alcalá (ES)
- Universidad Francisco de Vitoria (ES)
- McMaster University Medical Centre (CA)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario de La Princesa (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1748277
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00