Phenotypic, functional, prognostic and predictive significance of B-cell and antibody responses in human melanoma: A scoping review
We draw consensus for associations between class-switched B-cells and immune-active antibody isotypes that indicate heightened classical immunity, with improved immunotherapy response. While alternatively-activated, regulatory B-cells and immune-inert antibody isotypes associate with immunosuppression and less-favourable clinical outcomes. We reveal aspects of humoral immunity that offer opportunities to identify predictive biomarkers of immunotherapy response and irAEs.
Authors
- Thomas J Tull (ORCID: https://orcid.org/0000-0002-8329-8601)
- Alastair D. MacKenzie Ross (ORCID: https://orcid.org/0000-0001-7299-8656)
- Jenny L. C. Geh (ORCID: https://orcid.org/0000-0001-7031-3844)
- Lucy H. Booth
- Alexandra McCraw (ORCID: https://orcid.org/0009-0008-2412-4389)
- Sophia N. Karagiannis (ORCID: https://orcid.org/0000-0002-4100-7810)
- Sophia Tsoka (ORCID: https://orcid.org/0000-0001-8403-1282)
- Katie E. Lacy (ORCID: https://orcid.org/0000-0001-9694-9197)
- Hawys Lloyd-Hughes
- Katie Stoker (ORCID: https://orcid.org/0009-0002-7889-7164)
- Mauzammal Tahiri
- Xinyi Chen (ORCID: https://orcid.org/0000-0002-3511-8733)
- Yin Wu
- Joanna Jacków-Malinowska
- Mieke Van Hemelrijck
Institutions
- Guy's Hospital (GB)
- St Thomas' Hospital (GB)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Breast Cancer Now (GB)
- Translational Research in Oncology (FR)
- St. Thomas Hospital (CA)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/bjd/ljag074
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Argenx
- Cancer Research UK
- British Skin Foundation
- King's College London
- King's Health Partners
- Medical Research Council